故事围绕一支深入南美原始雨林的科考队展开，他们原本是为了研究稀有物种，却意外唤醒了一条沉睡千年的双头巨蟒。这种生物不仅体型庞大、行动迅捷，而且具备极高的智慧与攻击性，两个头颅仿佛拥有独立意识，协同猎杀，令人防不胜防。随着队员接连遭遇不幸，幸存者在绝境中逐渐揭开了怪蟒诞生的真相——它竟然是人类非法基因实验的产物。最终，主角团队在暴雨倾盆的废弃研究基地，以生命为代价设下陷阱，利用电磁脉冲装置干扰其神经中枢，将怪蟒引入自毁程序。
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